Number of pages: 100 | Report Format: PDF | Published date: March 21, 2023
Historical Years – 2021 | Base Year – 2022 | Forecasted Years – 2023-2031
Report Attribute |
Details |
Market Size Value in 2022 |
US$ 1.39 billion |
Revenue Forecast in 2031 |
US$ 4.21 billion |
CAGR |
13.1% |
Base Year for Estimation |
2022 |
Forecast Period |
2023-2031 |
Historical Year |
2021 |
Segments covered |
Sequencing Type, Product, Application, End User, and Region |
Regional Scope |
North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa |
According to the deep-dive market assessment study by Growth Plus Reports, the global NGS library preparation market was valued at US$ 1.39 billion in 2022 and is expected to register a revenue CAGR of 13.1% to reach US$ 4.21 billion by 2031.
NGS Library Preparation Market Fundamentals
The development of the NGS (Next-Generation Sequencing) library is an important stage in the process of collecting high-quality sequencing data utilizing NGS platforms. Many methods are involved in library preparation, including fragmentation of genomic DNA or RNA, adaptor ligation, and PCR amplification.
NGS is a powerful tool for genome sequencing, transcriptomics, epigenetics, metagenomics, and many other research fields. However, the DNA or RNA sample must be transformed into a proper library sequence before NGS. The development of an NGS library entails numerous processes that are crucial to the outcome of NGS experiments.
Sample preparation is followed by the fragmentation step, which involves extracting the DNA or RNA sample from the biological material and purifying it to eliminate impurities. The fragmentation step includes enzymes or mechanical shearing to break apart the DNA or RNA sample into smaller bits. End repair and adapter ligation steps include the ends of DNA or RNA fragments repaired to form blunt ends, and adapters are attached to the ends to enable amplification and sequencing. The size selection step uses gel electrophoresis, magnetic beads, or other techniques that are picked for a certain size range. The fragments are amplified using PCR to produce numerous copies of each fragment for sequencing.
NGS libraries can be used in genomics, transcriptomics, epigenetics, metagenomics, and other fields of study. NGS libraries are essential for preparing DNA or RNA samples for NGS sequencing and producing high-quality sequencing data for downstream analysis.
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NGS Library Preparation Market Dynamics
The increasing demand for sequencing and awareness of genomics in healthcare primarily drives the global NGS library preparation market. There has been a tremendous increase in the usage of sequencing technology in recent years, as well as an increased awareness of genomics among healthcare practitioners. This has been fueled by technological advancements that have made sequencing more rapid, affordable, and precise. As a result, sequencing is currently employed in various applications, including cancer detection and treatment, customized medicine, and genetic testing.
As the frequency of genetic disorders increases, so does the demand for precise and efficient DNA sequencing technology to discover genetic variants and mutations that contribute to disease development. NGS technology has transformed genomics by allowing for high-throughput sequencing of DNA samples, allowing for a more complete and thorough investigation of genetic variation. NGS library preparation is an important step of NGS technology since it influences the quality of the sequencing data produced. As researchers and physicians attempt to discover disease-causing genetic mutations and variants more rapidly and precisely, the need for NGS library preparation will likely grow.
Market participants are launching initiatives to improve the quality and efficiency of NGS library preparation and expand its application in new research and clinical practice fields. They also collaborate with prominent research institutes and healthcare organizations to develop and verify NGS-based solutions for various applications. These collaborations ensure that NGS solutions are customized for specific applications and satisfy the demands of researchers and clinicians.
NGS Library Preparation Market Ecosystem
The global NGS library preparation market is analyzed from five perspectives: sequencing type, product, application, end user, and region.
NGS Library Preparation Market by Sequencing Type
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Based on sequencing type, the global NGS library preparation market is segmented into whole genome sequencing, targeted genome sequencing, whole exome sequencing, and other sequencing types.
The targeted genome sequencing segment dominates the global NGS library preparation market. Targeted genome sequencing is used to investigate a subset of genomic regions with a special emphasis on specific genes or genomic locations. This approach is used in producing NGS libraries. It involves capturing the specified areas using particular genomic probes or primers and sequencing those sections for comprehensive study. Compared to whole-genome sequencing, this method saves time, resources, and money while offering excellent accuracy and depth of coverage for the targeted regions.
The whole genome sequencing segment is anticipated to grow in the forecast period. Whole genome sequencing provides a complete picture of an organism’s genetic material, allowing researchers to identify all variations, including single-nucleotide polymorphisms, insertions, and deletions. Additionally, whole genome sequencing enables the discovery of new genes and non-coding regions that may play important roles in gene regulation. Moreover, by comparing whole genomes from different species, researchers can identify genes that have been conserved throughout evolution, providing insights into their function and importance.
NGS Library Preparation Market by Product
Based on the product, the global NGS library preparation market is segmented into reagents & consumables, and instruments.
The reagents & consumables segment accounted for the majority of revenue share in 2022. Reagents and consumables play a crucial role in the success of NGS library preparation by ensuring accuracy, reproducibility, and high-quality sequencing data. They also save time and effort by providing pre-optimized protocols that eliminate the need for extensive optimization and troubleshooting.
The instruments segment is anticipated to show lucrative revenue growth during the forecast period. Instruments used in NGS library preparation offer several advantages, such as high throughput, accuracy, reproducibility, and reduced hands-on time. These instruments also enable the automation of library preparation, which reduces human error and increases efficiency.
NGS Library Preparation Market by Application
Based on application, the global NGS library preparation market is segmented into drug & biomarker discovery, disease diagnostics, and others.
The drug & biomarker discovery segment accounted for the majority of revenue share in 2022. NGS library preparation allows for identifying potential drug targets and biomarkers much faster than traditional methods, leading to more efficient drug discovery and personalized medicine. Additionally, the high-throughput nature of NGS enables the analysis of large amounts of data, increasing the probability of identifying rare genetic variants that may be associated with the disease.
The disease diagnostics segment is anticipated to grow higher during the forecast period. NGS library preparation for disease diagnostics offers several advantages, including the ability to simultaneously detect multiple pathogens and the potential for higher sensitivity and specificity than traditional diagnostic methods. Additionally, NGS can provide valuable information on the genetic diversity and evolution of pathogens, which can aid in developing effective treatment strategies.
NGS Library Preparation Market by End User
Based on end user, the global NGS library preparation market is segmented into hospitals and clinics, academic and research institutions, pharmaceutical and biotechnology companies, and others.
The academic and research institutions segment accounts for the majority of the global NGS library preparation market revenue share. NGS library preparation methods offer several advantages to academic and research institutions, including high throughput, cost-effectiveness, and the ability to immediately generate large amounts of data. These methods also enable the detection of rare variants and provide a more comprehensive view of genomic regions of interest.
The hospitals & clinics segment is expected to register revenue growth with high revenue CAGR in the forecast years. NGS library preparation methods have revolutionized how genetic testing is performed in hospitals and clinics, allowing for faster and more accurate diagnosis. Additionally, these methods have enabled the identification of new genetic variants and disease-causing mutations, leading to improved patient treatment options.
NGS Library Preparation Market by Region
Based on the region, the global NGS library preparation market is segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.
North America accounted for the highest revenue share of the market in 2022. This is due to the widespread usage of sequencing technology and NGS sample preparation sequencing solutions. Furthermore, the increase in NGS-based clinical and research applications and favorable government and private sector initiatives for developing and deploying NGS technologies all contribute to the revenue growth of the regional market.
The Europe NGS library preparation market is characterized by increasing healthcare standards and rising uptake of biotechnology techniques in diagnostics and research and development. Additionally, the revenue growth in this region is also influenced by the presence of many academic research labs. Moreover, the presence of powerful research centers and hospitals supporting scientific innovations in Europe also supports the NGS library preparation market.
The market in Asia Pacific is projected to grow rapidly during the forecast period due to the increasing advancements in medical research, the rising popularity of specialized therapies, and the presence of top players in the region. Moreover, the revenue growth of Asia Pacific is influenced by increasing R&D in the region.
NGS Library Preparation Market Competitive Landscape
Several companies emphasize development tactics, such as new launches, product approvals, and other elements like patents and events. The market observed acquisition, partnership, and cooperation activities as inorganic development strategies. These initiatives have enabled the expansion of future economic business prospects and increased demand in the global NGS library preparation market.
The prominent companies with the largest revenue share in the global NGS library preparation market are:
NGS Library Preparation Market Strategic Developments
The global NGS library preparation market is expected to reach US$ 4.21 billion by 2031.
Over the years, NGS library preparation has revolutionized the field of research and development, diagnostics, and medical research.
The global NGS library preparation market is expected to register a revenue CAGR of 13.1% during the forecast period.
North America accounted highest revenue share of the global market in 2022.
*Insights on financial performance are subject to the availability of information in the public domain