Number of pages: 100 | Report Format: PDF | Published date: April 19, 2023
Historical Years – 2021 | Base Year – 2022 | Forecasted Years – 2023-2031
Report Attribute |
Details |
Market Size Value in 2022 |
US$ 6.70 Billion |
Market Size Value in 2031 |
US$ 9.84 billion |
CAGR |
4.36% |
Base Year For Estimation |
2022 |
Forecast Period |
2023 to 2031 |
Historical Year |
2021 |
Segments Covered |
Drug Type, Indication, Route of Administration, Distribution Channel, and Region |
Regional Scope |
North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa |
According to the deep-dive market assessment study by Growth Plus Reports, the global mTOR inhibitors market was valued at US$ 6.70 billion in 2022 and is expected to register a revenue CAGR of 4.36% to reach US$ 9.84 billion by 2031.
mTOR Inhibitors Market Fundamentals
mTOR (mammalian target of rapamycin) inhibitors are a class of drugs that target the mTOR protein, a central regulator of cell growth and metabolism. The mTOR pathway plays a key role in regulating cell growth, proliferation, and survival, and its dysregulation is associated with many diseases, including cancer, diabetes, and neurodegenerative disorders. These inhibitors work by blocking the activity of the mTOR protein, which reduces the production of proteins and other cellular components necessary for cell growth and division. By doing so, they can slow down or stop the growth of cancer cells. There are two main classes of mTOR inhibitors: Rapalogs and ATP-competitive. Rapalogs are derived from the natural product rapamycin and work by binding to a specific protein called FKBP12, which in turn binds to mTOR and inhibits its activity. ATP-competitive inhibitors bind to the ATP-binding site of mTOR and inhibit its activity differently. mTOR inhibitors have been approved to treat certain types of cancer, including renal cell carcinoma, breast cancer, and pancreatic neuroendocrine tumors. They are also being studied in non-cancerous diseases such as autoimmune disorders and neurodegenerative diseases.
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mTOR Inhibitors Market Dynamics
The mTOR inhibitors market is expected to show lucrative revenue growth during the forecast period. With the growing incidence of cancer worldwide, the demand for mTOR inhibitors is expected to rise. Technological advances have led to the development of new mTOR inhibitors with improved efficacy and fewer side effects, driving market revenue growth. As the global population ages, age-related diseases are also increasing. This is expected to drive the demand for mTOR inhibitors, commonly used in treating these diseases. Pharmaceutical companies are investing heavily in research and development activities to develop new and innovative mTOR inhibitors, expected to drive market revenue growth during the forecast period. There is a growing awareness among patients and healthcare professionals about the importance of early diagnosis and effective treatment of cancer. This is expected to increase the demand for mTOR inhibitors, considered an important tool in the fight against cancer. Governments worldwide are promoting research and development, which is expected to further drive the need for the mTOR inhibitors market during the forecast period.
The mTOR inhibitors market is subject to stringent regulations by various regulatory bodies, which can hinder the market’s revenue growth. The cost of mTOR inhibitors is high, making it difficult for patients to afford treatment. Besides, mTOR inhibitors can cause various side effects, including stomatitis, diarrhea, and infections, which can limit their use in patients. The efficacy of mTOR inhibitors is limited in some cancers, which can limit their use in these indications. Several alternative therapies are available for cancer treatment, which restricts the revenue growth of the mTOR inhibitors market. Some cancer cells can develop resistance to mTOR inhibitors, which can limit their effectiveness. There is limited awareness about mTOR inhibitors among patients and physicians, which can limit their adoption.
mTOR Inhibitors Market Ecosystem
The global mTOR inhibitors have been analyzed from five perspectives: drug type, indication, route of administration, distribution channel, and region.
mTOR Inhibitors Market by Drug Type
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Based on drug type, the global mTOR inhibitors market is segmented into Everolimus, Temsirolimus, Sirolimus, and others.
The everolimus segment accounts for a prominent revenue share in the global mTOR inhibitors market. Everolimus works by interfering with the growth of cancer cells, which are eventually destroyed by the body. Since the growth of normal body cells can also be affected, other unwanted effects will also occur. It belongs to the medicines known as antineoplastics (cancer medicines). Drugs like Everolimus and Letrozole have succeeded in slowing tumor development by either eradicating the cells or preventing them from growing or spreading. Everolimus is a drug that belongs to the class of mTOR (mammalian target of rapamycin) inhibitors, which treat various types of cancer, including renal cell carcinoma, breast cancer, and pancreatic neuroendocrine tumors. The dominance of Everolimus in the global mTOR inhibitor market can be attributed to several factors. Everolimus has been approved for treating multiple types of cancers, making it a versatile drug that can treat many patients. This has allowed Everolimus to capture a larger market share than other mTOR inhibitors approved for a more limited range of indications. Moreover, Everolimus has a favorable safety profile compared to other mTOR inhibitors. The drug is generally well-tolerated by patients and has fewer adverse events than other drugs.
mTOR Inhibitors Market by Indication
Based on indication, the global mTOR inhibitors market is segmented into oncology, immunosuppressant, organ transplantation, and others.
The oncology segment dominates the global mTOR inhibitor market with the largest revenue share. The mTOR pathway plays a key role in cancer cell growth and survival, making it an attractive target for cancer therapy. According to the World Health Organization (WHO), cancer is one of the leading causes of death worldwide, with an estimated 10 million deaths in 2020. As the global burden of cancer continues to increase, there is a growing demand for effective cancer therapies, including mTOR inhibitors. In addition, a favorable regulatory environment supports the oncology segment of the mTOR inhibitor market. Regulatory agencies, such as the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA), have granted fast-track and priority review status to several mTOR inhibitors in oncology, allowing for expedited approval and faster patient access to these drugs.
mTOR Inhibitors Market by Route of Administration
Based on the route of administration, the global mTOR inhibitors market is segmented into oral and intravenous.
Oral mTOR inhibitors are more convenient for patients as they can be self-administered at home without needing hospital visits. This makes them more appealing to patients who want to maintain their quality of life while receiving treatment. Oral mTOR inhibitors are highly effective in the treatment of various diseases. They work by inhibiting the activity of the mammalian target of rapamycin (mTOR) protein, which plays a critical role in the growth and proliferation of cancer cells. Oral mTOR inhibitors are generally safe and well-tolerated by patients. They have a favorable side-effect profile compared to other cancer treatments, such as chemotherapy. Oral mTOR inhibitors are often less expensive than other cancer treatments, which makes them more accessible to patients who may not have insurance or who have limited financial resources. Oral mTOR inhibitors are widely available and can be prescribed by doctors in most countries. This makes them a popular choice for physicians who want to provide their patients with effective treatment options.
mTOR Inhibitors Market by Distribution Channel
Based on the distribution channel, the global mTOR inhibitors market is segmented into hospital pharmacies, online pharmacies, and retail pharmacies.
The hospital segment accounts for the largest global mTOR inhibitor market revenue share. The use of mTOR inhibitors for cancer treatment requires close monitoring and management due to the complex nature of the treatment. This complexity often requires hospitalization and the involvement of specialized medical personnel. Therefore, the hospital segment dominates as they have the resources and personnel to manage the complexities associated with mTOR inhibitor therapy. Hospitals have access to specialized equipment and facilities required to administer and monitor mTOR inhibitors. This equipment includes infusion pumps, specialized laboratory equipment, and monitoring devices for safe and effective treatment. Mammalian targets of rapamycin (mTOR) inhibitors are classified as high-risk drugs, and their use requires strict adherence to regulatory requirements. Hospitals can meet these requirements due to their established infrastructure, policies, and procedures. Physicians specializing in cancer treatment may prefer to administer mTOR inhibitors in a hospital setting due to the complexities associated with the treatment. The hospital setting provides a controlled environment where patients can be closely monitored, and any adverse reactions can be promptly managed.
mTOR Inhibitors Market by Region
Based on the region, the global mTOR inhibitors market is segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.
North America’s highly advanced healthcare infrastructure includes well-established hospitals, specialized cancer treatment centers, and research institutions. This infrastructure supports the development and distribution of mTOR inhibitors, contributing to the region’s dominance in the global market. North America has a high prevalence of cancer, which has driven the demand for mTOR inhibitors. The region has an increased incidence of various types of cancer, including breast, lung, and prostate, contributing to the market revenue growth. North America has a high level of healthcare spending, which has supported the development and distribution of mTOR inhibitors. The region’s high healthcare spending has enabled the development of advanced medical technologies, including mTOR inhibitors, which have contributed to the region’s dominance in the global mTOR inhibitors market revenue share. North America’s strong pharmaceutical industry has been at the forefront of mTOR inhibitor research and development.
mTOR Inhibitors Market Competitive Landscape
The prominent players operating in the global mTOR inhibitors market are:
mTOR Inhibitors Market Strategic Development
The global mTOR inhibitors market is expected to grow at a revenue CAGR of 4.36% during the forecast period.
Novartis AG, Pfizer Inc, Teva Pharmaceutical Industries Ltd., and Zydus Lifesciences Limited are the key players operating in the global mTOR inhibitors market.
The oncology segment accounts for the largest global mTOR inhibitors market revenue share.
Europe accounts for the second-largest revenue share in the global mTOR inhibitors market.
Stringent regulatory policies, the high cost of mTOR inhibitors, and the side effects of mTOR inhibitors are among the major challenges in global mTOR inhibitors market revenue expansion.
*Insights on financial performance are subject to the availability of information in the public domain