Leucovorin Calcium Market
Number of pages: 100 | Report Format: PDF | Published date: March 29, 2023
Historical Years – 2021 | Base Year – 2022 | Forecasted Years – 2023-2031
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Report Attribute |
Details |
|
CAGR |
13.8% |
|
Base Year for Estimation |
2022 |
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Forecast Period |
2023-2031 |
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Historical Year |
2021 |
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Segments Covered |
Type, Application, Distribution Channel, and Region |
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Regional Scope |
North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa |
According to the deep-dive market assessment study by Growth Plus Reports, the global leucovorin calcium market is expected to register growth at a revenue CAGR of 13.8% from 2023 to 2031.
Leucovorin Calcium Market Fundamentals
Leucovorin is a folate analog used to alleviate the toxic effects of methotrexate and other folate antagonists, cure megaloblastic anemia, and treat colorectal cancer palliatively. It is an antidote to drugs acting as folic acid antagonists. Leucovorin can be used to offset the therapeutic and harmful effects of folic acid antagonists, such as methotrexate, which work by blocking dihydrofolate reductase. Leucovorin is also used to improve the action of fluorouracil. Leucovorin boosts fluorouracil activity by solidifying the active metabolites to the enzyme thymidylate synthetase to treat osteosarcoma (after high-dose methotrexate therapy). It is used to reduce toxicity and counteract the effects of poor methotrexate clearance and unintentional folic acid antagonist overdosages, as well as to treat megaloblastic anemia caused by the folic acid shortage.
The leucovorin calcium market is estimated to show notable revenue growth in the predicted timeframe due to increasing cases of blood-related disorders and the rising prevalence of cancer. Additionally, a rise in the geriatric population and an increase in awareness of the effectiveness of combination therapy are propelling the market revenue growth. Moreover, leucovorin calcium has been found to have potential applications in treating autoimmune diseases, further driving market revenue growth.
Leucovorin Calcium Market Dynamics
The rising incidence of cancer is a major driver of the revenue growth of the leucovorin calcium market. Leucovorin calcium is combined with chemotherapy to treat various types of cancer, including colorectal, breast, lung, and ovarian cancer. Additionally, the geriatric population is at a higher risk of developing cancer, and the rise in this population is driving the demand for cancer treatments. Combination therapy, which involves multiple drugs to treat cancer, is more effective than single-agent therapy. Leucovorin calcium is often used with other chemotherapy drugs. It helps enhance the efficacy of certain chemotherapy drugs, particularly those used to treat colorectal cancer, by increasing their ability to kill cancer cells. In addition, leucovorin calcium has potential applications in treating autoimmune diseases, such as rheumatoid arthritis and Crohn’s disease. Leucovorin calcium can also help reduce the toxicity of chemotherapy drugs by minimizing their impact on normal cells, particularly in the bone marrow, which can lead to anemia, low white blood cell counts, and an increased risk of infection. Leucovorin calcium has also been investigated for its potential usage in other conditions, such as osteoporosis, methotrexate toxicity, and alcoholism. Thus, these factors contribute to the revenue growth of the global leucovorin calcium market.
However, leucovorin calcium is a relatively expensive drug with low availability in some regions, limiting its usage and accessibility to patients. While leucovorin calcium is used off-label in combination with other chemotherapy drugs to enhance their efficacy, alternative treatments can achieve similar outcomes without using leucovorin calcium. Like all drugs, leucovorin calcium can cause side effects, including nausea, vomiting, and diarrhea. These side effects may limit its usage in some patients or lead to treatment discontinuation. Using leucovorin calcium in off-label drugs can pose regulatory challenges since it is not approved for usage in certain types of cancer. This can limit its usage and accessibility, particularly in regions with strict regulatory frameworks.
The global leucovorin calcium market is highly competitive, with several companies manufacturing and distributing the drug. Some leucovorin calcium patents have expired or are set to expire, which can lead to increased competition from generic drug manufacturers and pressure the drug’s pricing and profitability.
Leucovorin Calcium Market Ecosystem
The global leucovorin calcium market has been analyzed from four perspectives: type, application, distribution channel, and region.
Leucovorin Calcium Market by Type
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Based on type, the global leucovorin calcium market is segmented into tablets and injections.
The injections segment dominated the global leucovorin calcium market primarily due to the most preferred drug administration route in several medical conditions. When combined with chemotherapy drugs, Leucovorin calcium enhances the efficacy of chemotherapy by increasing the intracellular concentration of active metabolites. This leads to an increase in the antitumor activity of chemotherapy drugs. Injections of leucovorin calcium have a rapid onset of action and are preferred in critical conditions where fast action is required. In addition, injections of leucovorin calcium have a higher bioavailability than other routes of administration, which means that a greater amount of the drug reaches the target tissue. Moreover, injections of leucovorin calcium are convenient to administer in hospitalized patients and can be rapidly titrated to achieve the desired therapeutic effect.
Leucovorin Calcium Market by Application
Based on application, the global leucovorin calcium market can be segmented into blood cell disorders, cancer, and others.
The blood cell disorder segment is estimated to account for a substantial revenue share of the global leucovorin calcium market. Blood cell disorders, such as anemia, neutropenia, and thrombocytopenia, affect the production or function of red blood cells, white blood cells, or platelets in the body. Various factors, including genetic mutations, autoimmune disorders, infections, and certain medications, can cause these disorders. Leucovorin calcium is often used as a supportive therapy in treating these disorders, as it can help stimulate the production of new blood cells and improve overall health. The revenue growth of this segment can be majorly attributed to the high prevalence of blood cell disorders across the globe and the increase in demand for effective treatment options. Additionally, as the population ages and the incidence of cancer and other chronic illnesses continues to rise, the need for supportive therapies, such as leucovorin calcium, will likely increase.
The cancer segment is also estimated to illustrate lucrative revenue growth during the projected timeframe attributed to the rapidly growing cases of colorectal cancer among the people. For instance, according to the International Agency for Research on Cancer, colorectal cancer was listed as the third most common cancer type globally in 2020, with almost 2 million cases diagnosed. Risk factors associated with colorectal cancer are inflammatory bowel diseases, such as Crohn’s disease or ulcerative colitis, hereditary colorectal cancer or colorectal polyps, and the lack of physical activity. Additionally, a low-fiber and high-fat diet, or a diet high in processed meats, overweight or obesity, alcohol consumption, and tobacco use. Thus, all these factors further contribute to the revenue growth of this segment, thereby propelling the global market.
Leucovorin Calcium Market by Distribution Channel
Based on the distribution channel, the global leucovorin calcium market can be further segmented into hospital pharmacies, retail pharmacies, and online pharmacies.
The hospital pharmacies segment dominated the global leucovorin calcium market as hospitals are the primary healthcare providers for patients with cancer and other serious medical conditions requiring leucovorin calcium treatment. Additionally, hospital pharmacies have the infrastructure and resources to store and manage large inventories of drugs, including leucovorin calcium, which is often used in high volumes. Moreover, hospitals have specialized medical staff trained in administering chemotherapy drugs, including leucovorin calcium. This expertise ensures that patients receive the correct dosage and that potential side effects are managed effectively. As a result, hospitals are the primary location for administering leucovorin calcium, making hospital pharmacies a key segment in the global market for this drug.
Leucovorin Calcium Market by Region
Based on the region, the global leucovorin calcium market can be segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.
The North America market is expected to exhibit significant revenue growth in the forecast period due to the growing population and increasing Internet penetration. The market revenue growth in this region can be attributed to advanced healthcare, the high prevalence of cancer, and a large base of aged people. Additionally, high healthcare expenditure with an advanced healthcare system and facilities further contributes to the market revenue growth in this region.
The primary reasons driving the Europe market are rising disposable income levels among individuals, increasing incidence rates of chronic diseases, such as cancer and type II diabetes, and an aging population suffering from different health issues.
The Asia Pacific market is expected to develop at the fastest revenue CAGR during the projected period. Advancing healthcare systems, improving medical facilities, and rising cancer and blood cell disorder cases also contribute to the revenue growth of the global market in this region.
Leucovorin Calcium Market Competitive Landscape
The prominent players operating in the global leucovorin calcium market are:
These companies are involved in various activities such as manufacturing, marketing, and distributing leucovorin calcium products. They are also engaged in research and development activities to develop innovative and more effective therapies. Additionally, companies are investing in mergers and acquisitions, partnerships, and collaborations to strengthen their market position. The competitive landscape of the leucovorin calcium market is expected to intensify in the coming years as new players enter the market and established companies expand their product portfolios.
Leucovorin Calcium Market Strategic Developments
The leucovorin calcium market is expected to register growth at a revenue CAGR of 13.8% during the projected period.
The blood cell disorders segment accounts for a significant revenue share of the global leucovorin calcium market.
The high cost and availability of alternatives are some of the major restraints for revenue growth in the global leucovorin calcium market.
The injections segment dominates the global leucovorin calcium industry.
The rise in the prevalence of blood cell disorders and colorectal cancers is driving revenue growth in the global leucovorin calcium market.
*Insights on financial performance are subject to the availability of information in the public domain