Human Liver Model Market
Number of pages: 100 | Report Format: PDF | Published date: February 10, 2023
Historical Years – 2020 | Base Year – 2021 | Forecasted Years – 2022-2030
|
Report Attribute |
Details |
|
Market Size Value in 2021 |
US$ 1.39 billion |
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Revenue Forecast in 2030 |
US$ 3.98 billion |
|
CAGR |
12.4% |
|
Base Year For Estimation |
2021 |
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Forecast Period |
2022-2030 |
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Historical Year |
2020 |
|
Segments Covered |
Type, Application, End-users, and Region |
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Regional Scope |
North America, Europe, Asia Pacific, and the Rest of the World (RoW) |
According to the deep-dive market assessment study by Growth Plus Reports, the global human liver model market was valued at US$ 1.39 billion in 2021 and is expected to register a revenue CAGR of 12.4% to reach US$ 3.98 billion by 2030.
Human Liver Model Market Fundamentals
The liver is a crucial organ that carries out several crucial body processes, including bile generation for digestion, protein synthesis, blood clotting factor synthesis, glucose storage in the form of glycogen, and detoxifying chemicals and metabolizing drugs. A human liver model is a structure used to examine the toxicity of a medicine that can lead to liver failure and other liver illnesses. It allows a better understanding of liver illness and the complicated spatial linkages of the liver’s internal structure. Advanced liver models are mini-organs or organoids that are designed to mimic human liver physiology, architecture, and functions from the molecular layer up. The development of these live models is a novel field of study that has the potential to replace animal models.
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Human Liver Model Market Dynamics
Human liver modeling is a trending industry with high popularity among researchers and scientists and is expected to illustrate enormous revenue growth during the projected period. Liver models are created by developing a virtual environment from single fetal progenitor liver cells. Continuous increase in the prevalence of diseases such as cancer and non-alcoholic fatty liver diseases and rise in the research to develop novel treatments are some of the key factors driving the demand for liver models. Liver disease is one of the major causes of death globally. Around 1.5 million annual deaths were reported in 2017 due to a lack of medical treatment and transplantable organs. The market revenue growth can also be ascribed to increase in healthcare research and development (preclinical and clinical research) and breakthroughs in organ printing technology.
The human liver models find application in various parts of the medical field, such as reducing the risk of drug-induced liver injury in humans, modeling human liver diseases, and enabling cell-based therapies in clinics. It also has its application in elucidating the role of single and combinatorial microenvironmental cues on liver cell function. Moreover, growing emphasis on developing alternatives to animal-based models and accuracy in outcomes is also expected to drive market expansion. Furthermore, continuously growing competition amongst prominent players in the market is leading to their adoption of various growth strategies, such as the development and launch of new products and expanding and diversifying their market presence by acquiring a new client base. These factors encourage the revenue growth of the human liver model market.
However, the high cost of liver models and challenges with integrating liver models into current workflows are expected to hinder market expansion throughout the projected period.
Human Liver Model Market Ecosystem
The global human liver model market has been analyzed from four perspectives: type, application, end-users, and region.
Human Liver Model Market by Type
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Based on type, the global human liver model market has been segmented into liver organoids, animal models, liver-on-a-chip, 3D bioprinting, and 2D models.
The liver-on-a-chip segment dominates the market with the largest revenue share. Chips enable in vitro research on different processes and the development of liver disorders. They also play a key function in medication testing to suppress or cure them. Liver-on-a-chip systems provide much-needed cues, such as perfusion, shear stress, and three-dimensional (3D) cell-cell contact, making them a viable alternative to traditional, static two-dimensional (2D) cultures. Since the human liver is the metabolic center and plays a significant role in the effectiveness and clearance of systemic therapies, liver chips are of special interest in drug research. Additionally, this system is one of the best alternatives to animal models, is modest, cost-effective, and can maintain metabolic activities similar to the in vivo environment, thus contributing to the revenue growth of this segment.
The 3D bioprinting segment is also estimated to show considerable revenue growth during the projected period. This 3D bioprinting technology enables and enhances the recapitulation of hepatocyte organization and cell-matrix contacts, the inclusion of additional cell types, the incorporation of fluid flow, and the creation of oxygen and nutrient gradients, resulting in improved differentiated cell phenotype and functionality. Thus, assisting the researchers in efficiently developing geometrically well-defined 3D scaffolds seeded with cells. Hence, encouraging the overall revenue growth of the segment.
Human Liver Model Market by Application
Based on the application, the global human liver model market has been segmented into academics, drug discovery, and others.
The drug discovery segment dominates the market with the largest revenue share due to increasing cases of chronic diseases globally. Liver models play a crucial role in preclinical drug development and prove beneficial for drug testing. As conventional preclinical models are frequently restricted to a certain point and cannot detect drug toxicity, the dangers these treatments pose to humans can only be discovered in clinical trials. This results in a time-consuming and expensive procedure for the pharmaceutical industry to develop fallacious medications. For developing a potential drug, advanced technologies, such as human liver models (especially liver-on-chip), are used widely as these models can mimic organ-level pathophysiology with clinical response.
Human Liver Model Market by End-User
According to end-user, the global human liver model market is segmented into research institutes & academics, pharmaceutical companies, and others.
The pharmaceutical companies segment accounts for the largest revenue share of the global market. Rising incidences of various rare diseases among the population play a crucial role in the revenue growth of this segment. The increasing prevalence of diseases boosts the need for effective and enhanced medical solutions for treatment, thereby propelling the pharmaceutical segment revenue growth. Additionally, with rising cases of chronic diseases and in oncology, the human liver model can greatly help develop novel treatments or therapy, hence encouraging the revenue growth of the pharmaceutical segment.
The research institutes & academics segment is estimated to illustrate lucrative revenue growth in the projected timeframe from 2022 to 2030. The revenue growth of this segment can be ascribed to rapidly increasing research activities in the pharmaceuticals and diagnostics space.
Human Liver Model Market by Region
The global human liver model market has been segmented based on regions into North America, Europe, Asia Pacific, and the Rest of the World.
North America registered the highest revenue share of the global market in 2021. The revenue growth of the human liver model market in this region can be attributed to a large base of pharmaceutical and biopharmaceutical industries (Life science industries) with a high penetration of human organoid technologies. Additionally, rapidly growing cases of rare and chronic diseases among the population; hence, a large need for novel and advanced treatment, bolster the market revenue growth in this region. Furthermore, the presence of advanced healthcare infrastructure due to the high adoption of next-generation technologies and large healthcare expenditure by the government also encourages the overall revenue growth of the North America human liver model market.
Human Liver Model Market Competitive Landscape
The prominent players operating in the global human liver model market are:
Human Liver Model Market Strategic Development/s
The global human liver model market is expected to be valued at US$ 3.98 billion by 2030.
The high cost of liver models and challenges with integrating liver models into current workflows are expected to hinder market expansion throughout the projected period.
The global human liver model market is expected to register growth at a revenue CAGR of 12.4% during the forecast period from 2022 to 2030.
The global human liver model market was estimated to be US$ 1.39 billion in 2021.
CB Information Services Inc., Organovo Holding Inc., Mimetas BV, InSphero, and BioIVT are among the top market players.
*Insights on financial performance are subject to the availability of information in the public domain