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Gene Synthesis Market

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Gene Synthesis Market

Gene Synthesis Market by Method (Oligonucleotide Synthesis and Gene Assembly), by Application (Disease Diagnosis, Gene & Cell Therapy development, Vaccine Development and Others), by End User (Academic and Research Institutes, Biopharmaceuticals Company, Contract Research Organization) – Global Outlook & Forecast Period 2022-2030

GR - 537349 Category: Biotechnology

Number of pages: 100  |  Report Format: PDF  |  Published date: November 10, 2022

Historical Years – 2020  |  Base Year – 2021  |  Forecasted Years – 2022-2030


Gene Synthesis Market Scope

Report Attribute

Details

Market size value in 2021

US$ 2 billion

Revenue forecast in 2030

US$ 3.99 billion

Growth Rate

CAGR of 8% from 2022 to 2030

Base year for estimation

2021

Forecast period

2022-2030

Segments covered

By Method, Application, End User and Region.

Regional scope

North America, Europe, Asia Pacific, and the Rest of the World (ROW)

Report Overview

The global gene synthesis market was pegged at US$ 2 billion in 2021 and is expected to witness a CAGR of 8% during the forecast period.

Market Fundamental 

In vitro chemical production of double-stranded DNA molecules is known as gene synthesis. It is a tool used in biotechnology and has a significant impact on synthetic biology. Gene therapy, the creation of vaccines, molecular engineering, and heterologous gene expression are just a few of the recombinant DNA technology applications where the technology has emerged as a key tool. It can assist in creating new enzymes for the treatment of cancer. Additionally, it can be used to diagnose viral genomes in real-time vaccine development. Without using a template DNA strand, gene synthesis can create mutated, recombinant, or completely new DNA sequences.

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Market Dynamic 

One of the main drivers of the worldwide gene synthesis market's expansion is the rise of start-up businesses operating in the sector, as well as increased research and development expenditures for gene synthesis methodologies and technological developments. However, in the next years, the growth of the worldwide gene synthesis market may be constrained by a lack of qualified specialists and rigid, time-consuming approval procedures.

Market Ecosystem

The market has been analysed into four perspectives by method, application, end user and region.  

Gene Synthesis Market by Method

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Based on method, the global gene synthesis market has been segmented into oligonucleotide synthesis and gene assembly. The oligonucleotide synthesis is sub segmented into solid phase phosphoramidite synthesis, and microchip-based oligonucleotide synthesis whereas gene assembly is also sub segmented into ligation-mediated assembly and PCR mediated assembly.  The gene assembly segment dominated the market during forecast period. Oligonucleotides up to 120–150 nucleotides (nt) in length are frequently produced via chemical synthesis, which is a step in the gene synthesis process. For this reason, in most cases, tiny oligonucleotides are connected using gene assembly techniques in order to create the gene of the desired length. To combine relatively short synthetic oligonucleotides into larger gene sequences, a number of techniques have been created over the past three decades. One of the most popular methods for mediating assembly of the desired DNA sequence is the polymerase chain reaction (PCR) - mediated assembly.

Gene Synthesis Market by Application 

Based on application, the global gene synthesis market has been segmented into disease diagnosis, gene & cell therapy development, vaccine development and others. The gene and cell therapy segment dominated the segment during forecast period due to the active development of novel treatments by corporations and academic institutions around the world, which has increased access to cutting-edge medications for the treatment of chronic diseases.

Gene Synthesis Market by End User

Based on end user, the gene synthesis market has been segmented into academic and research institutes, biopharmaceuticals company, contract research organization. The academic and research institute dominated the segment during forecast period. Research institutions are collaborating with service providers to expedite their projects that require the synthesis and characterisation of gene fragments, and gene synthesis services are frequently used in study plans.

Gene Synthesis Market by Region

Based on region, the gene synthesis market has been segmented into North America, Europe, Asia Pacific and Rest of the Word. The market for gene synthesis is now dominated by North America, and this dominance is anticipated to continue for a while. In North America, the US holds the largest market share. The ageing population, rising frequency of hereditary and chronic diseases like cancer, growing need for specialised treatment, and supportive government initiatives are the main factors driving the large market. Additionally, due to growing demand from academic institutions and biopharmaceutical companies, as well as the existence of a sizable number of industry participants with a reliable distribution route Twist Bioscience, for instance, increased its revenue by US$68.3 million in 2018 as a result of scaling up and commercialising their silicon chip-based technology for high throughput, low-cost gene synthesis. Thus, this component helped to further develop the local market.

The recent approval of a large number of cellular and gene therapies in the region also encourages additional businesses to invest in this domain. Because of the growing investments made by international corporations in the regional industry, Asia Pacific is predicted to have the fastest CAGR. Additionally, the expansion of the industry is aided by the presence of several important corporations in developing countries like China and India.

Competitive Landscape 

Some of the prominent player in the global gene synthesis market include 

Strategic Development  

  • In December 2020, clonal-ready gene fragments were released by Twist Bioscience to complete the gene offering. To produce the best clones, the fragments launched might be employed with or without adapters. The clonal-ready gene fragments work with a variety of processes, including gene expression, enzyme engineering, and protein expression pathways.
  • In 2020, globally, an estimated 19.3 million new cases of cancer and about 10.0 million cancer deaths were reported, according to a study published in an ACS journal. This shows that cancer coverage is not at its best, and there is a pressing need to increase cancer coverage globally.
  • In April 2022, for users of the SYNTAX system, DNA Script developed an early access programme, through which businesses can have early access to the most recent developments in their enzymatic DNA synthesis technology.

Frequently Asked Questions About This Report

The Asia Pacific is the key growth region in the global gene synthesis market.

The rising R&D in the field of genomics and next generation sequencing, increasing demand for personalized medicine and rising government funding toward genomics.

The global gene synthesis market is expected to clock US$ 3.99 billion by 2030

The global gene synthesis market was pegged is expected to witness a CAGR of 8% during the forecast period.

Some of the prominent player in the global gene synthesis market include GenScript, Brooks Automation, Inc. (GENEWIZ) and others.

Table of Content

  1. INTRODUCTION
    1. Market Ecosystem 
    2. Timeline Under Consideration
      1. Historical Years - 2020
      2. Base Years - 2021
      3. Forecasted Years – 2022 to 2030 
    3. Currency Used in the Report
  2. RESEARCH METHODOLOGY 
    1. Research Approach
    2. Data Collection Methodology
    3. Data Sources
      1. Secondary Sources 
      2. Primary Sources 
    4. Market Estimation Approach
      1. Bottom Up 
      2. Top Down 
    5. Market Forecasting Model
    6. Limitations and Assumptions       
  3. PREMIUM INSIGHTS
    1. Current Market Trend (COVID-19 Perspective)
    2. Key Players & Competitive Positioning (2021) 
  4. MARKET DYNAMICS
    1. Drivers
    2. Restraints/Challenges
    3. Opportunities
  5. GLOBAL GENE SYNTHESISMARKET - ANALYSIS & FORECAST, BY METHOD
    1. Oligonucleotide Synthesis 
      1. Solid Phase Phosphoramidite Synthesis
      2.  Microchip-Based Oligonucleotide Synthesis
    2. Gene Assembly
      1. Ligation-Mediated Assembly
      2. PCR Mediated Assembly
  6. GLOBAL GENE SYNTHESIS MARKET - ANALYSIS & FORECAST, BY APPLICATION
    1. Disease Diagnosis
    2. Gene & Cell Therapy development
    3. Vaccine Development
    4.  Others
  7. GLOBAL GENE SYNTHESIS MARKET - ANALYSIS & FORECAST, BY END USER
    1. Academic and Research Institutes
    2. Biopharmaceuticals Company
    3. Contract Research Organization
  8. GLOBAL GENE SYNTHESIS MARKET - ANALYSIS & FORECAST, BY REGION
    1. North America Gene Synthesis Market
      1. North America Gene Synthesis Market, by Method
      2. North America Gene Synthesis Market, by Application
      3. North America Gene Synthesis Market, by End User
      4. North America Gene Synthesis Market, by Country
        1. U.S.
          1. U.S. Gene Synthesis Market, by Method
          2. U.S. Gene Synthesis Market, by Application
          3. U.S. Gene Synthesis Market, by End User
        2. Canada
          1. Canada Gene Synthesis Market, by Method
          2. Canada Gene Synthesis Market, by Application
          3. Canada Gene Synthesis Market, by End User
    2. Europe Gene Synthesis Market
      1. Europe Gene Synthesis Market, by Method
      2. Europe Gene Synthesis Market, by Application
      3. Europe Gene Synthesis Market, by End User
      4. Europe Gene Synthesis Market, by Country/Region
        1. Germany
          1. Germany Gene Synthesis Market, by Method
          2. Germany Gene Synthesis Market, by Application
          3. Germany Gene Synthesis Market, by End User
        2. U.K.
          1. U.K. Gene Synthesis Market, by Method
          2. U.K. Gene Synthesis Market, by Application
          3. U.K. Gene Synthesis Market, by End User
        3. Spain
          1. Spain Gene Synthesis Market, by Method
          2. Spain Gene Synthesis Market, by Application
          3. Spain Gene Synthesis Market, by End User
        4. Italy 
          1. Italy Gene Synthesis Market, by Method
          2. Italy Gene Synthesis Market, by Application
          3. Italy Gene Synthesis Market, by End User
        5. France
          1. France Gene Synthesis Market, by Method
          2. France Gene Synthesis Market, by End User
          3. France Gene Synthesis Market, by Application
        6. Rest of Europe 
          1. Rest of Europe Gene Synthesis Market, by Method
          2. Rest of Europe Gene Synthesis Market, by Application
          3. Rest of Europe Gene Synthesis Market, by End User
    3. Asia Pacific Gene Synthesis Market
      1. Asia Pacific Gene Synthesis Market, by Method
      2. Asia Pacific Gene Synthesis Market, by Application
      3. Asia Pacific Gene Synthesis Market, by End User
      4. Asia Pacific Gene Synthesis Market, by Country/Region
        1. China
          1. China Gene Synthesis Market, by Method
          2. China Gene Synthesis Market, by Application
          3. China Gene Synthesis Market, by End User
        2. Japan
          1. Japan Gene Synthesis Market, by Method
          2. Japan Gene Synthesis Market, by Application
          3. Japan Gene Synthesis Market, by End User
        3. India
          1. India Gene Synthesis Market, by Method
          2. India Gene Synthesis Market, by Application
          3. India Gene Synthesis Market, by End User
        4. South Korea
          1. South Korea Gene Synthesis Market, by Method
          2. South Korea Gene Synthesis Market, by Application
          3. South Korea Gene Synthesis Market, by End User
        5. Australia
          1. Australia Gene Synthesis Market, by Method
          2. Australia Gene Synthesis Market, by Application
          3. Australia Gene Synthesis Market, by End User
        6. Rest of Asia Pacific 
          1. Rest of Asia Pacific Gene Synthesis Market, by Method
          2. Rest of Asia Pacific Gene Synthesis Market, by Application
          3. Rest of Asia Pacific Gene Synthesis Market, by End User
    4. Rest of the World Gene Synthesis Market
      1. Rest of the World Gene Synthesis Market, By Region
        1. Rest of the World Gene Synthesis Market, by Method
        2. Rest of the World Gene Synthesis Market, by Application
        3. Rest of the World Gene Synthesis Market, by End User
        4. Latin America
          1. Latin America Gene Synthesis Market, by Method
          2. Latin America Gene Synthesis Market, by Application
          3. Latin America Gene Synthesis Market, by End User
        5. Middle East & Africa
          1. Middle East & Africa Gene Synthesis Market, by Method
          2. Middle East & Africa Gene Synthesis Market, by Application
          3. Middle East & Africa Gene Synthesis Market, by End User
  9. COMPANY PROFILES        
    1. GenScript
      1. Business Snapshot 
      2. Products/Services Offered
      3. Financial Details*
      4. Strategic Developments
    2. Brooks Automation, Inc. (GENEWIZ)
    3.  Boster Biological Technology
    4. Twist Bioscience
    5. ATDBio Ltd.
    6. ProteoGenix
    7.  Biomatik
    8. Bioneer Corporation
    9. ProMab Biotechnologies, Inc.
    10. Thermo Fisher Scientific, Inc.
    11. Eurofins Scientific
    12. Eurogentec
    13.  Integrated DNA Technologies, Inc.
    14.  OriGene Technologies, Inc.

*Insights on financial performance is subject to availability of information in public domain


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