Digital PCR (dPCR) and Real-Time PCR (qPCR) Market
Number of pages: 100 | Report Format: PDF | Published date: June 10, 2021
Historical Years – 2021 | Base Year – 2022 | Forecasted Years – 2023 to 2031
|
Report Attribute |
Details |
|
Market Size Value in 2022 |
US$ 36.23 billion |
|
Revenue Forecast in 2031 |
US$ 78.21 billion |
|
CAGR |
8.0% |
|
Base Year for Estimation |
2022 |
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Forecast Period |
2023 to 2031 |
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Historical Year |
2021 |
|
Segments Covered |
Technology, Product, Application, End User, and Region |
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Regional Scope |
North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa |
According to the deep-dive market assessment study by Growth Plus Reports, the global digital PCR (dPCR) and real-time PCR (qPCR) market was valued at US$ 36.23 billion in 2022 and is expected to register a revenue CAGR of 8.0% to reach US$ 78.21 billion by 2031.
Digital PCR (dPCR) and Real-Time PCR (qPCR) Market Fundamentals
Digital PCR is a technique used to precisely quantify the amount of DNA or RNA in a sample. It involves partitioning the sample into numerous small, individual reactions, each containing either a single molecule or no molecule at all. Each partitioned reaction is then subjected to PCR amplification. After amplification, the partitions are analyzed to determine the presence or absence of the target molecule. By counting the number of positive and negative partitions, the absolute quantity of the target molecule in the original sample can be determined.
Real-time PCR, also known as quantitative PCR, is a technique used to amplify and quantify specific DNA or RNA sequences in real time during the PCR reaction. It utilizes fluorescent reporter molecules, such as DNA-binding dyes or sequence-specific probes, which emit fluorescence when bound to the amplified product. The accumulation of fluorescence is measured after each PCR cycle, allowing for the continuous monitoring of amplification. The fluorescence data can be used to calculate the initial amount of target molecules present in the sample using a standard curve or comparative methods.
Digital PCR (dPCR) and Real-Time PCR (qPCR) Market Dynamics
The increasing demand for accurate and rapid diagnostic methods in areas such as infectious diseases, genetic disorders, and cancer is driving the digital PCR (dPCR) and real-time PCR (qPCR) market. PCR plays a crucial role in molecular diagnostics due to its sensitivity, specificity, and ability to detect and quantify nucleic acids. As per statistics provided by ReAct (a SIDA-funded organization), bacterial infection was determined to be responsible for 7.7 million deaths worldwide. That accounts for 13.6%, or 1 in 8, of all deaths worldwide. The digital PCR (dPCR) and real-time PCR (qPCR) market outlook is positive as the field of genomics and proteomics continues to expand, focusing on understanding genetic variations, gene expression, and protein analysis. PCR-based techniques, including qPCR, dPCR, and multiplex PCR, are essential tools for studying gene expression, genotyping, and DNA sequencing. The demand for POC testing is increasing as it allows for rapid, on-site diagnostics, reducing the turnaround time for test results. PCR-based technologies, including isothermal amplification techniques like LAMP (Loop-mediated Isothermal Amplification), are being developed and utilized for POC applications, enabling quick and accurate detection of pathogens or genetic markers. PCR plays a vital role in therapeutic applications such as infectious disease management, cancer treatment, and pharmacogenomics. It facilitates the detection of pathogens, monitoring of disease progression, identification of genetic markers for targeted therapies, and assessment of drug efficacy, thus boosting the digital PCR (dPCR) and real-time PCR (qPCR)market demand.
However, digital PCR (dPCR) and real-time PCR (qPCR) techniques often require specialized instruments, reagents, and consumables, which can be costly. The initial investment in instrumentation and ongoing reagent expenses restricts the digital PCR (dPCR) and real-time PCR (qPCR)market growth. Digital PCR (dPCR) and real-time PCR (qPCR) techniques can be technically demanding and require optimization for specific applications. Factors such as primer design, reaction conditions, template quality, and the presence of inhibitors can impact the success and reliability of digital PCR (dPCR) and real-time PCR (qPCR) assays which is also hindering the digital PCR (dPCR) and real-time PCR (qPCR) market growth.
Digital PCR (dPCR) and Real-Time PCR (qPCR) Market Ecosystem
The global digital PCR (dPCR) and real-time PCR (qPCR)market is analyzed from five perspectives: technology, product, application, end user, and region.
Digital PCR (dPCR) and Real-Time PCR (qPCR) Market by Technology
Based on the technology, the global digital PCR (dPCR) and real-time PCR (qPCR)market is segmented into digital PCR (dPCR) and real-time PCR (qPCR).
The real-time PCR (qPCR) segment accounted for the largest revenue share of the digital PCR (dPCR) and real-time PCR (qPCR) market. Real-time PCR has been widely adopted and utilized for many years, establishing itself as a well-established and trusted technique. Its robustness, versatility, and proven performance have made it the go-to method for many molecular biology applications, including gene expression analysis, pathogen detection, and genotyping. qPCR is suitable for a wide range of applications, including gene expression analysis, quantification of nucleic acids, detection of infectious agents, genetic testing, and diagnostic assays. Its versatility has made it the method of choice for various research fields, clinical laboratories, and industrial applications. qPCR instruments are capable of processing a larger number of samples in a single run compared to digital PCR. This higher throughput makes qPCR more suitable for applications where many samples, such as high-throughput screening or diagnostic laboratories, need to be processed.
Digital PCR (dPCR) and Real-Time PCR (qPCR) Market by Product
Based on the products, the global digital PCR (dPCR) and real-time PCR (qPCR)market is segmented into instruments, reagents & consumables, software & services.
The reagents & consumable segment accounted for the prominent digital PCR (dPCR) and real-time PCR (qPCR) market share in 2022, with a 58% market share. Reagents and consumables are fundamental components of the PCR workflow, as they are required for sample preparation, amplification, and detection of target nucleic acids. Reagents and consumables are routinely used in PCR experiments, making them essential and frequently purchased items for laboratories and researchers. As PCR techniques are employed in diverse applications, such as gene expression analysis, genotyping, pathogen detection, and molecular diagnostics, the demand for reagents and consumables remains consistently high. Reagents and consumables are consumable products that must be replenished regularly as they are depleted with each PCR experiment. Laboratories and researchers require a continuous supply of these items to ensure the smooth execution of their PCR assays, contributing to the recurring nature of purchases in this segment.
Digital PCR (dPCR) and Real-Time PCR (qPCR) Market by Application
Based on the applications, the global digital PCR (dPCR) and real-time PCR (qPCR) market is segmented into clinical applications, research applications, and forensic applications.
The clinical applications segment accounted for the highest revenue share of the digital PCR (dPCR) and real-time PCR (qPCR) market, with an 83% market share. The clinical applications segment is further sub-segmented into oncology testing, pathogen testing, liquid biopsy, and others. PCR techniques, including dPCR and qPCR, are widely used in clinical applications for disease diagnosis and monitoring. These techniques enable the detection and quantification of specific DNA or RNA sequences associated with various diseases, including infectious diseases, genetic disorders, and cancers. The ability of PCR to provide sensitive and accurate results makes it a valuable tool for clinical diagnostics. According to GLOBOCAN 2020 report, approximately 10 million deaths were cases by cancer in 2020. PCR is extensively used in cancer research and diagnostics. It enables the detection of specific mutations, gene rearrangements, and changes in gene expression associated with different types of cancer. The demand for molecular diagnostics is increasing due to the shift towards precision medicine and the need for accurate and rapid diagnostic methods. PCR techniques offer high sensitivity, specificity, and the ability to quantify nucleic acids, making them indispensable in the clinical laboratory for accurate disease detection, monitoring, and treatment decisions.
Digital PCR (dPCR) and Real-Time PCR (qPCR) Market by End User
Based on the end users, the global digital PCR (dPCR) and real-time PCR (qPCR) market is segmented into hospitals, academic institutes & research centers, diagnostic centers, and others.
The hospitals segment accounted for a significant digital PCR (dPCR) and real-time PCR (qPCR) market share in 2022. Hospitals are major healthcare facilities that provide a wide range of diagnostic services to patients. PCR techniques, including dPCR and qPCR, are integral to clinical diagnostics in hospitals. These techniques are used for the detection and quantification of various diseases, including infectious diseases, genetic disorders, and cancers. Hospitals typically have well-established infrastructure, including dedicated molecular diagnostics laboratories equipped with PCR instruments and facilities. They also have skilled laboratory professionals, including molecular biologists and medical technologists, who are trained in performing PCR assays and interpreting the results. This infrastructure and expertise enable hospitals to efficiently conduct PCR-based testing and offer reliable diagnostic services. Hospitals use PCR techniques to guide patient care and treatment decisions. PCR-based tests help in selecting appropriate antimicrobial therapies, monitoring treatment response, detecting drug resistance, and identifying genetic markers that impact treatment outcomes.
Digital PCR (dPCR) and Real-Time PCR (qPCR) Market by Region
Geographically, the global digital PCR (dPCR) and real-time PCR (qPCR) market has been segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.
The North America region has the largest digital PCR (dPCR) and real-time PCR (qPCR) market size in terms of revenue generation accounting for around 33% share of the market. Molecular diagnostics, including dPCR and qPCR, are witnessing growing demand in North America. The need for accurate and rapid diagnostic methods for infectious diseases, genetic disorders, and cancer is driving the adoption of PCR techniques in clinical settings. The ability of dPCR and qPCR to provide sensitive and specific results makes them valuable tools for disease detection, monitoring, and treatment decisions. According to the WHO, in 2020, 2.2 million new cancer cases were diagnosed in U.S. North America is home to several leading market players in the PCR industry, including instrument manufacturers, reagent suppliers, and service providers. These companies invest in research and development, marketing, and distribution networks to promote dPCR and qPCR technologies. North America is a hub for scientific research and has a strong academic and research community. PCR techniques are widely used in various fields, including genomics, proteomics, microbiology, and cancer research.
Digital PCR (dPCR) and Real-Time PCR (qPCR) Competitive Landscape
The prominent players operating in the global digital PCR (dPCR) and real-time PCR (qPCR)market are:
Digital PCR (dPCR) and Real-Time PCR (qPCR) Strategic Developments
Digital PCR is a technique used to precisely quantify the amount of DNA or RNA in a sample. It involves partitioning the sample into numerous small, individual reactions, each containing either a single molecule or no molecule at all. Real-time PCR, also known as quantitative PCR, is a technique used to amplify and quantify specific DNA or RNA sequences in real time during the PCR reaction.
Asia Pacific can be considered the key growth region due to the surge in digital PCR (dPCR) and real-time PCR (qPCR) industry trends in China, Japan, and the Indian subcontinent.
The prominent players operating in the global digital PCR (dPCR) and real-time PCR (qPCR) market are Thermo Fisher Scientific Inc., Abbott Laboratories, F. Hoffmann-La Roche Ltd., BIOMÉRIEUX, and Agilent Technologies, Inc.
The global digital PCR (dPCR) and real-time PCR (qPCR) market growth is estimated to be at a revenue CAGR of 8% during the forecast period from 2023 to 2031.
The estimated size of the global digital PCR (dPCR) and real-time PCR (qPCR) market in 2031 is US$ 78.21 billion.
*Insights on financial performance are subject to the availability of information in the public domain