Number of pages: 100 | Report Format: PDF | Published date: April 14, 2023
Historical Years – 2021 | Base Year – 2022 | Forecasted Years – 2023-2031
Report Attribute |
Details |
CAGR |
2.7% |
Base Year For Estimation |
2022 |
Forecast Period |
2023 to 2031 |
Historical Year |
2021 |
Segments Covered |
Treatment, End User, and Region |
Regional Scope |
North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa |
According to the deep-dive market assessment study by Growth Plus Reports, the global autosomal dominant hypocalcemia type 1 is expected to register a revenue CAGR of 2.7% from 2023 to 2031.
Autosomal Dominant Hypocalcemia Type 1 Market Fundamentals
Autosomal dominant hypocalcemia type 1 (ADH1) is a rare genetic disorder characterized by abnormally low levels of calcium in the blood. This condition is caused by mutations in the CASR gene, which is responsible for developing the calcium-sensing receptor protein. The calcium-sensing receptor has a crucial role in regulating the amount of calcium in the blood. When calcium levels are low, the receptor stimulates the release of a parathyroid hormone, which helps increase calcium levels. However, in people with ADH1, mutations in the CASR gene causes the calcium-sensing receptor to be less responsive to changes in calcium levels, leading to low levels of calcium in the blood. Symptoms of ADH1 may include muscle cramps, spasms, twitches, numbness and tingling in the hands and feet, and even seizures.
In some cases, patients with ADH1 can also suffer from low levels of magnesium in the blood, thus causing additional symptoms such as fatigue, weakness, and abnormal heart rhythms. The traditional treatment for ADH1 involves taking calcium and vitamin D supplements to raise calcium levels in the blood. Treatment options for ADH1 may include medications, such as diazoxide or octreotide, to help regulate insulin secretion and dietary modifications to maintain stable blood sugar levels. In some cases, surgical intervention, such as a partial or total pancreatectomy, can also be considered. In some cases, medications such as acidimetric may also be used to help increase the sensitivity of the calcium-sensing receptor. Regular monitoring of calcium and magnesium levels is important to ensure effective treatment and prevent complications such as kidney stones and bone loss.
Autosomal Dominant Hypocalcemia Type 1 Market Dynamics
Increasing awareness of ADH1 among healthcare professionals and people has led to earlier diagnosis and treatment of the disease. Since ADH1 is a rare disease, it evolves diagnostic methods, enabling early detection of symptomatic and non-symptomatic patients. The unmet medical need due to the well-defined treatment for DH1 is driving the development of new treatments for the disease. Additionally, regulatory bodies such as the FDA (Food and Drug Administration) and EMA (The European Medicines Agency) are also supporting the development of treatments for rare diseases.
Moreover, some opportunities can bolster the market revenue growth during the forecast period, such as advances in research, specifically in understanding the genetic basis of ADH1, which can lead to the development of new treatments for the condition. This can include novel pharmacological or gene therapies addressing the underlying genetic defects. Moreover, there is a growing rate of patient awareness through advocacy and support groups. The rising influence of social media is also playing a key role in attracting attention to this disease group. Market players, drug developers, research institutions, healthcare facilities, and patient groups are also frequently collaborating, augmenting the overall awareness about the disease and the current treatment options. Collaboration between researchers, healthcare professionals, patient advocacy groups, and regulators can also help to address the challenges facing the ADH1 market. Since ADH1 is a rare disease, the treatments for such a medical condition are eligible for orphan drug designation. This can provide financial incentives, including tax credits and reduced regulatory fees, to encourage the development of treatments for the condition. Advances in precision medicine can enable the development of targeted treatments for ADH1 based on an individual's specific genetic defect. This could improve treatment outcomes and reduce the risk of adverse effects.
Currently, there are several challenges and constraints faced by the global autosomal dominant hypocalcemia type 1 market that can impact the development and commercialization of treatments for such a rare medical condition. Although awareness of ADH1 is growing, many healthcare professionals still poorly understand the condition. This can lead to delays in diagnosis and treatment and limit the market for ADH1 treatments. The pathophysiology of ADH1 is complex and not entirely understood yet. This is creating challenges in the way of developing effective treatments for the condition. Limited clinical data are available on the safety and efficacy of treatments for ADH1, making it difficult for regulators to approve new treatments and physicians to prescribe them confidently. Developing treatments for rare diseases like ADH1 can be expensive due to the small patient population and the need to conduct extensive clinical trials to demonstrate safety and efficacy.
Autosomal Dominant Hypocalcemia Type 1 Market Ecosystem
The global autosomal dominant hypocalcemia type 1 market is analyzed from three perspectives: treatment, end user, and region.
Autosomal Dominant Hypocalcemia Type 1 Market by Treatment
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Based on the treatment, the global autosomal dominant hypocalcemia type 1 market is segmented into calcium analogs and vitamin analogs.
The calcium analog segment accounts for a prominent revenue share in the global autosomal dominant hypocalcemia type 1 market. Calcium analogs, such as calcitriol and calcium supplements, are the mainstay in managing autosomal dominant hypocalcemia type 1. They are effective at managing the symptoms of the disease and are widely available and accessible. As of the current scenario, there are limited treatment options available for ADH1, which means that calcium analogs are often the only sustainable option for patients with the condition. Calcium analogs are inexpensive and cost-effective, making them an attractive option for healthcare providers. There is a significant body of clinical evidence supporting the use of calcium analogs in the treatment of ADH1. This evidence has demonstrated their safety and efficacy, contributing to their widespread adoption of the standard of care. Calcium analogs have minimal side effects, which makes them well-tolerated by patients with ADH1. This can improve patient compliance and quality of life.
According to several studies, vitamin D insufficiency can also reduce glucose metabolism and insulin production, exacerbating hypoglycemia episodes in people with ADH1 and increasing the demand for vitamin analogs. Vitamin D has also been implicated in regulating insulin sensitivity, which may enhance insulin receptor expression and function. Furthermore, some research has indicated that vitamin D supplementation has a beneficial effect on glucose metabolism and insulin sensitivity in individuals with diabetes, which can potentially extend to ADH1 as well. People with ADH1 have low levels of calcium in their blood, which can cause symptoms such as muscle cramps, seizures, and fatigue. Vitamin D2 or D3 (ergocalciferol or cholecalciferol, respectively) or vitamin D metabolites [calcitriol or 1,25-(OH)2 vitamin D or 1 alpha-OH vitamin D (not available in the US)] are frequently required for people with autosomal dominant hypocalcemia type 1. However, due to less evidence, there is a need for research to fully understand the potential role of vitamin D in the growth of ADH1.
Autosomal Dominant Hypocalcemia Type 1 Market by End User
Based on the end user, the global autosomal dominant hypocalcemia type 1 market is segmented into hospitals, clinics, and others.
Since hospitals have a large patient pool, it is considered the primary healthcare facility, accounting for the largest revenue share in the global autosomal dominant hypocalcemia type 1 market. Additionally, as the number of instances of hypocalcemia rises, so does the demand for rapid diagnosis and treatments. Additionally, hospitals provide well-skilled healthcare practitioners with novel diagnostic and management systems. Furthermore, the presence of reimbursement policies and high patient satisfaction rates further fuels the revenue growth of this segment, thereby propelling the overall market growth.
Autosomal Dominant Hypocalcemia Type 1 Market by Region
Based on the region, the global autosomal dominant hypocalcemia type 1 market is segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.
The market for autosomal dominant hypocalcemia type 1 treatment in North America is relatively small due to the rare nature of the condition. In North America, the treatment of ADH1 is typically managed by a multidisciplinary team of healthcare professionals, including endocrinologists, geneticists, and other specialists. Due to the rarity of ADH1, there may be limited commercial interest in developing specialized treatments for this condition.
Similarly, Europe's autosomal dominant hypocalcemia type 1 market is expected to grow slowly. Europe has a well-established healthcare infrastructure with advanced medical facilities, trained healthcare professionals, and sophisticated medical technologies. Additionally, Europe is also home to many of the leading research institutions across the globe. Europe has an aging population, and older adults are more likely to develop hypocalcemia, thus contributing to the growing demand for diagnosis and management drugs for treating autosomal dominant hypocalcemia type 1 in the region.
Autosomal Dominant Hypocalcemia Type 1 Market Competitive Landscape
New product approvals and launches, promising product pipelines, and mergers and acquisitions can provide ample growth opportunities for the companies operating in the market. The prominent players operating in the global autosomal dominant hypocalcemia type 1 market are:
Autosomal Dominant Hypocalcemia Type 1 Market Strategic Development
Autosomal dominant hypocalcemia (ADH) type 1 is caused by heterozygous activating mutations in the CASR, which increase the sensitivity of the CASR to extracellular ionized calcium.
The global autosomal dominant hypocalcemia type 1 market is expected to register a revenue CAGR of 2.7% from 2023 to 2031.
The calcium analogs segment accounts for a prominent revenue share in the global autosomal dominant hypocalcemia type 1 market with the largest revenue share.
Limited knowledge about the disease and lack of standard treatment are some of the restraints in the global autosomal dominant hypocalcemia type 1 market revenue growth.
Some market players operating in the global autosomal dominant hypocalcemia type 1 market are BridgeBio Inc., Shire (Takeda), and F. Hoffmann-La Roche AG.
*Insights on financial performance are subject to the availability of information in the public domain